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despite its relatively recent approval by the food and drug administration and the guideline recommendations, the therapeutic use of digoxin is declining in patients with heart failure likely the result of several factors.

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gastrointestinal reactions hepatitis, hepatic failure, pancreatitis, bloody diarrhea, impaired folic acid absorption, impaired digoxin absorption, stomatitis, diarrhea, abdominal pains, and neutropenic enterocolitis.

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